BMAL1 moonlighting as a gatekeeper for LINE1 repression and cellular senescence in primates

BMAL1 moonlighting as a gatekeeper for LINE1 repression and cellular senescence in primates

Aging in humans is intricately linked with alterations in circadian rhythms concomitant with physiological decline and stem cell exhaustion. However, whether the circadian machinery directly regulates stem cell aging, especially in primates, remains poorly understood. In this study, we found that de...

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Bibliographic Details
Main Authors: Belmonte, J.C.I (Author), Chen, H. (Author), Hu, J. (Author), Ji, Z. (Author), Jiang, X. (Author), Ke, Q. (Author), Lai, X. (Author), Li, W. (Author), Liang, C. (Author), Liu, G.-H (Author), Liu, Z. (Author), Long, X. (Author), Ma, M. (Author), Qu, J. (Author), Ren, J. (Author), Sun, H. (Author), Wang, C. (Author), Wang, H. (Author), Wang, Q. (Author), Wang, S. (Author), Wang, Z. (Author), Wu, Z. (Author), Xia, K. (Author), Xiang, A.P (Author), Yan, H. (Author), Yang, K. (Author), Zhang, W. (Author)
Format: Article
Language:English
Published: Oxford University Press 2022
Subjects:
animal
Animals
ARNTL Transcription Factors
cell aging
Cellular Senescence
Circadian Clocks
circadian rhythm
Circadian Rhythm
genetics
heterochromatin
Heterochromatin
Macaca fascicularis
metabolism
primate
Primates
transcription factor ARNTL
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