7,8-Dihydro-8-oxo-1,N6-ethenoadenine: an exclusively Hoogsteen-paired thymine mimic in DNA that induces A→T transversions in Escherichia coli

7,8-Dihydro-8-oxo-1,N6-ethenoadenine: an exclusively Hoogsteen-paired thymine mimic in DNA that induces A→T transversions in Escherichia coli

This work investigated the structural and biological properties of DNA containing 7,8-dihydro-8-oxo-1,N6-ethenoadenine (oxo-ϵA), a non-natural synthetic base that combines structural features of two naturally occurring DNA lesions (7,8-dihydro-8-oxoadenine and 1,N6-ethenoadenine). UV-, CD-, NMR spec...

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Bibliographic Details
Main Authors: Aralov, A.V (Author), Cabrero, C. (Author), Croy, R.G (Author), Dukova, S. (Author), Essigmann, J.M (Author), Fedeles, B.I (Author), González, C. (Author), Gubina, N. (Author), Isaakova, E.A (Author), Khrulev, A.A (Author), Melnik, D. (Author), Ryazantsev, D.Y (Author), Tsvetkov, V.B (Author), Turaev, A.V (Author), Varizhuk, A.M (Author), Zatsepin, T.S (Author)
Format: Article
Language:English
Published: Oxford University Press 2022
Subjects:
base pairing
Base Pairing
DNA
DNA repair
DNA Repair
Escherichia coli
genetics
thymine
Thymine
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