Global chromosome rearrangement induced by CRISPR-Cas9 reshapes the genome and transcriptome of human cells
Chromosome rearrangement plays important roles in development, carcinogenesis and evolution. However, its mechanism and subsequent effects are not fully understood. Large-scale chromosome rearrangement has been performed in the simple eukaryote, wine yeast, but the relative research in mammalian cel...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Oxford University Press
2022
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| Online Access: | View Fulltext in Publisher |