Predicting base editing outcomes using position-specific sequence determinants

Predicting base editing outcomes using position-specific sequence determinants

CRISPR/Cas base editors promise nucleotide-level control over DNA sequences, but the determinants of their activity remain incompletely understood. We measured base editing frequencies in two human cell lines for two cytosine and two adenine base editors at ∼14 000 target sequences and find that bas...

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Bibliographic Details
Main Authors: Allen, F. (Author), Crepaldi, L. (Author), Ho, U.L (Author), Koeppel, J. (Author), Pallaseni, A. (Author), Parts, L. (Author), Peets, E.M (Author), Van Leeuwen, J. (Author), Vanderstichele, T. (Author), Weller, J. (Author)
Format: Article
Language:English
Published: Oxford University Press 2022
Subjects:
adenine
Adenine
CRISPR Cas system
CRISPR-Cas Systems
cytosine
Cytosine
gene editing
Gene Editing
human
Humans
metabolism
nucleotide
Nucleotides
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