The human AP-endonuclease 1 (APE1) is a DNA G-quadruplex structure binding protein and regulates KRAS expression in pancreatic ductal adenocarcinoma cells

The human AP-endonuclease 1 (APE1) is a DNA G-quadruplex structure binding protein and regulates KRAS expression in pancreatic ductal adenocarcinoma cells

Pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive types of cancer, is characterized by aberrant activity of oncogenic KRAS. A nuclease-hypersensitive GC-rich region in KRAS promoter can fold into a four-stranded DNA secondary structure called G-quadruplex (G4), known to regulate KR...

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Bibliographic Details
Main Authors: Bhakat, K.K (Author), Chen, Y. (Author), Khutsishvili, I. (Author), Marky, L.A (Author), Natarajan, A. (Author), Pramanik, S. (Author), Ray, S. (Author), Singh, P.K (Author), Song, H. (Author)
Format: Article
Language:English
Published: Oxford University Press 2022
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