Protein carbamylation and chronic kidney disease progression in the Chronic Renal Insufficiency Cohort Study

Protein carbamylation and chronic kidney disease progression in the Chronic Renal Insufficiency Cohort Study

Background: Protein carbamylation is a post-translational protein modification caused, in part, by exposure to urea's dissociation product cyanate. Carbamylation is linked to cardiovascular outcomes and mortality in dialysis-dependent end-stage kidney disease (ESKD), but its effects in earlier...

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Main Authors: Allegretti, A.S (Author), Appel, L.J (Author), Berg, A.H (Author), Chen, J. (Author), Deo, R. (Author), Feldman, H.I (Author), Frydrych, A. (Author), Go, A.S (Author), He, J. (Author), Kalim, S. (Author), Karumanchi, S.A (Author), Lash, J.P (Author), Nelson, R.G (Author), Nigwekar, S. (Author), Rahman, M. (Author), Raj, D. (Author), Rao, P.S (Author), Shafi, T. (Author), Shah, V.O (Author), Sondheimer, J. (Author), Srivastava, A. (Author), Thadhani, R. (Author), Townsend, R.R (Author), Unruh, M.L (Author), Weir, M. (Author), Zhao, S. (Author)
Format: Article
Language:English
Published: Oxford University Press 2022
Subjects:
carbamylation
chronic kidney failure
CKD
cohort analysis
Cohort Studies
complication
disease exacerbation
Disease Progression
Glomerular Filtration Rate
glomerulus filtration rate
human
Humans
Kidney Failure, Chronic
mortality
progression
Protein Carbamylation
Renal Insufficiency, Chronic
urea
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