Evaluation of Tumor DNA Sequencing Results in Patients with Gastric and Gastroesophageal Junction Adenocarcinoma Stratified by TP53 Mutation Status

Evaluation of Tumor DNA Sequencing Results in Patients with Gastric and Gastroesophageal Junction Adenocarcinoma Stratified by TP53 Mutation Status

BACKGROUND: Gastric cancer (GC) and gastroesophageal junction adenocarcinomas (GEJ) are molecularly diverse. TP53 is the most frequently altered gene with approximately 50% of patients harboring mutations. This qualitative study describes the distinct genomic alterations in GCs and GEJs stratified b...

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Bibliographic Details
Main Authors: Cen, L. (Author), Dineen, S.P (Author), Fontaine, J. (Author), Frakes, J. (Author), Hoffe, S.E (Author), Mehta, R. (Author), Mo, Q. (Author), Pimiento, J.M (Author), Walko, C.M (Author), Wood, A.C (Author), Zhang, Y. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
adenocarcinoma
Adenocarcinoma
DNA
DNA sequence
DNA sequencing
DNA, Neoplasm
Esophagogastric Junction
gastric cancer
gastroesophageal cancer
gastroesophageal junction
genetics
human
Humans
mutation
Mutation
mutation analysis
pathology
phosphatidylinositol 3 kinase
Phosphatidylinositol 3-Kinases
protein p53
Sequence Analysis, DNA
TP53
TP53 protein, human
Tumor Suppressor Protein p53
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