Metformin-mediated mitochondrial protection post-cardiac arrest improves EEG activity and confers neuroprotection and survival benefit

Metformin-mediated mitochondrial protection post-cardiac arrest improves EEG activity and confers neuroprotection and survival benefit

Cardiac arrest (CA) produces global ischemia/reperfusion injury resulting in substantial multiorgan damage. There are limited efficacious therapies to save lives despite CA being such a lethal disease process. The small population of surviving patients suffer extensive brain damage that results in s...

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Bibliographic Details
Main Authors: Becker, L.B (Author), Chillale, R.K (Author), Choudhary, R.C (Author), Frankfurt, M. (Author), Haque, S. (Author), Kim, J. (Author), Kim, N. (Author), Miyara, S.J (Author), Molmenti, E.P (Author), Shoaib, M. (Author), Yin, T. (Author), Zanos, S. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
animal
Animals
Brain Injuries
brain injury
cardiac arrest
disease model
Disease Models, Animal
electroencephalogram
electroencephalography
Electroencephalography
heart arrest
Heart Arrest
human
Humans
ischemia/reperfusion injury
metformin
Metformin
Mitochondria
mitochondrial protection
mitochondrion
neuroprotection
Neuroprotection
rat
Rats
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