Kidney transplantation from triple-knockout pigs expressing multiple human proteins in cynomolgus macaques

Kidney transplantation from triple-knockout pigs expressing multiple human proteins in cynomolgus macaques

Porcine cells devoid of three major carbohydrate xenoantigens, αGal, Neu5GC, and SDa (TKO) exhibit markedly reduced binding of human natural antibodies. Therefore, it is anticipated that TKO pigs will be better donors for human xenotransplantation. However, previous studies on TKO pigs using old wor...

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Bibliographic Details
Main Authors: Coe, T.M (Author), Colvin, R.B (Author), Curtis, M. (Author), Hall, K.C (Author), Hirose, T. (Author), Kan, Y. (Author), Kawai, T. (Author), Lassiter, G. (Author), Layer, J.V (Author), Ma, D. (Author), Markmann, J.F (Author), Matheson, R. (Author), Paragas, V.B (Author), Qin, W. (Author), Queiroz, L.M (Author), Rickert, C.G (Author), Rosales, I. (Author), Sasaki, H. (Author), Stiede, K. (Author), Westlin, W.F (Author), Yang, L. (Author), Youd, M.E (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2022
Subjects:
adult
animal
animal cell
animal experiment
animal model
animal tissue
Animals
Animals, Genetically Modified
antibody titer
Article
CD20 antibody
CD4+ T lymphocyte
CD40 ligand monoclonal antibody
controlled study
enoxaparin
female
ganciclovir
gene expression
genetics
graft rejection
Graft Rejection
graft survival
human
Humans
ketorolac
kidney transplantation
Kidney Transplantation
knockout gene
long term survival
lymphocyte subpopulation
Macaca fascicularis
male
methylprednisolone
methylprednisolone sodium succinate
mycophenolate mofetil
nonhuman
outcome assessment
pig
protein derivative
protein expression
rapamycin
recombinant erythropoietin
regulator protein
Swine
T cell depletion
tacrolimus
thrombosis
thymocyte antibody
transgene
transgenic animal
Transplantation, Heterologous
tumor xenograft
xenograft
xenotransplantation
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