E239K mutation abolishes the suppressive effects of lysine-specific demethylase 1 on migration and invasion of MCF7 cells

Lysine-specific demethylase 1 (LSD1) is an important histone demethylase that mediates epithelial to mesenchymal transition (EMT). The E239K mutation of LSD1 was identified in a luminal breast cancer patient from the COSMIC Breast Cancer dataset. To investigate the functional effects of the E239K mu...

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Bibliographic Details
Main Authors:	Hu, X. (Author), Li, Z. (Author), Liu, Z. (Author), Qian, R. (Author), Shi, Y. (Author), Wan, Y. (Author), Wu, T. (Author), Zhang, J. (Author), Zhang, Y. (Author), Zhao, B. (Author)
Format:	Article
Language:	English
Published:	John Wiley and Sons Inc 2022
Subjects:	adult alpha catenin animal animal experiment animal model animal tissue Animals Article breast cancer breast epithelium Breast Neoplasms breast tumor cell adhesion Cell Adhesion cell differentiation cell invasion cell migration cell motion Cell Movement claudin 3 controlled study epithelial mesenchymal transition epithelial to mesenchymal transition Epithelial-Mesenchymal Transition ERα ESR1 protein, human estrogen receptor alpha Estrogen Receptor alpha female Female GATA3 protein, human GATA3 Transcription Factor gene expression regulation Gene Expression Regulation, Neoplastic gene mutation genetics histone demethylase Histone Demethylases histone demethylation histone methylation human human cell Humans in vitro study KDM1A protein, human LSD1 lysine specific demethylase 1 MCF-7 cell line MCF-7 Cells metabolism metastatic breast cancer Mice missense mutation mouse mutation Mutation nonhuman oncogenomics pathology Pi3K/Akt signaling promoter region protein protein interaction RNA sequencing transcription factor GATA 3 transcription factor Slug tumor xenograft unclassified drug uvomorulin vimentin
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E239K mutation abolishes the suppressive effects of lysine-specific demethylase 1 on migration and invasion of MCF7 cells

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