Opportunities for Precision Treatment of GRIN2A and GRIN2B Gain-of-Function Variants in Triheteromeric N-Methyl-D-Aspartate Receptors

Opportunities for Precision Treatment of GRIN2A and GRIN2B Gain-of-Function Variants in Triheteromeric N-Methyl-D-Aspartate Receptors

N-methyl-D-aspartate receptors (NMDARs) are tetrameric assemblies of two glutamate N-methyl-D-aspartate receptor subunits, GluN1 and two GluN2, that mediate excitatory synaptic transmission in the central nervous system. Four genes (GRIN2A-D) encode four distinct GluN2 subunits (GluN2A-D). Thus, NMD...

Full description

Bibliographic Details
Main Authors: Allen, J.P (Author), Han, W. (Author), Kim, S. (Author), Myers, S.J (Author), Perszyk, R.E (Author), Shaulsky, G.H (Author), Traynelis, S.F (Author), Yuan, H. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
gain of function mutation
Gain of Function Mutation
hippocampus
Hippocampus
human
Humans
metabolism
n methyl dextro aspartic acid receptor
Receptors, N-Methyl-D-Aspartate
synaptic transmission
Synaptic Transmission
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items