SLAMF7 engagement superactivates macrophages in acute and chronic inflammation

SLAMF7 engagement superactivates macrophages in acute and chronic inflammation

Macrophages regulate protective immune responses to infectious microbes, but aberrant macrophage activation frequently drives pathological inflammation. To identify regulators of vigorous macrophage activation, we analyzed RNA-seq data from synovial macrophages and identified SLAMF7 as a receptor as...

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Bibliographic Details
Main Authors: Blazar, P. (Author), Brenner, M.B (Author), Chen, A.F (Author), Coblyn, J.S (Author), Dyer, G.S (Author), Earp, B.E (Author), Gomez-Rivas, E. (Author), Jeong, Y. (Author), Jonsson, A.H (Author), Kim, E.Y (Author), Lange, J.K (Author), Massarotti, E.M (Author), Nguyen, H.N (Author), Rao, D.A (Author), Simmons, D.P (Author), Sparks, J.A (Author), Todd, D.J (Author)
Format: Article
Language:English
Published: American Association for the Advancement of Science 2022
Subjects:
acute disease
Acute Disease
adult
Adult
Arthritis, Rheumatoid
cell culture
Cells, Cultured
chronic disease
Chronic Disease
COVID-19
Crohn disease
Crohn Disease
female
Female
genetics
human
Humans
immunology
inflammation
Inflammation
macrophage activation
Macrophage Activation
metabolism
pathology
physiology
procedures
Reverse Transcriptase Polymerase Chain Reaction
reverse transcription polymerase chain reaction
rheumatoid arthritis
RNA-Seq
SARS-CoV-2
signaling lymphocytic activation molecule
Signaling Lymphocytic Activation Molecule Family
single cell analysis
Single-Cell Analysis
SLAMF7 protein, human
Synovial Membrane
synovium
transcriptome
Transcriptome
virology
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Internet

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