Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort

The drivers of critical coronavirus disease 2019 (COVID-19) remain unknown. Given major confounding factors such as age and comorbidities, true mediators of this condition have remained elusive. We used a multi-omics analysis combined with artificial intelligence in a young patient cohort where majo...

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Main Authors:	Bahram, S. (Author), Bastard, P. (Author), Bernard, A. (Author), Bibi-Triki, S. (Author), Carapito, C. (Author), Carapito, R. (Author), Casanova, J.-L (Author), Chamaraux-Tran, T.-N (Author), Chittenden, T.W (Author), Collange, O. (Author), Danion, F. (Author), Drenou, B. (Author), Fafi-Kremer, S. (Author), Frappier, J. (Author), Gervais, A. (Author), Goichot, B. (Author), Guimaraes, R. (Author), Gujja, S. (Author), Gulcher, J.R (Author), Hanauer, A. (Author), Hansmann, Y. (Author), Helms, J. (Author), Hermine, O. (Author), Hirschler, A. (Author), Javad Aman, M. (Author), Kailasan, S. (Author), Kuteifan, K. (Author), Larnicol, A. (Author), Laumond, G. (Author), Lederle, A. (Author), Li, R. (Author), Lidar, D. (Author), Macquin, C. (Author), Malagon-Lopez, J. (Author), Mariette, X. (Author), Mayeur, S. (Author), Mertes, P.-M (Author), Meziani, F. (Author), Mohseninia, R. (Author), Molitor, A. (Author), Moog, C. (Author), Muller, L. (Author), Nilsson, P. (Author), Paul, N. (Author), Pichot, A. (Author), Pin, E. (Author), Pottecher, J. (Author), Radosavljevic, M. (Author), Rolli, V. (Author), Ruch, Y. (Author), Sanlaville, D. (Author), Schenck, M. (Author), Schmidt, S. (Author), Schneider, F. (Author), Sibilia, J. (Author), Simons, M. (Author), Spinnhirny, P. (Author), Stemmelen, T. (Author), Tahar, O. (Author), Tharaux, P.-L (Author), Thomas, A. (Author), Viari, A. (Author), Wu, H. (Author), Zhang, Q. (Author)
Format:	Article
Language:	English
Published:	American Association for the Advancement of Science 2022
Subjects:	ADAM protein ADAM Proteins ADAM9 protein, human adult Article artificial intelligence Artificial Intelligence artificial ventilation blood analysis blood clotting bone marrow cell causal modeling cell compartmentalization cohort analysis controlled study coronavirus disease 2019 COVID-19 critically ill patient cytokine cytology deep learning differential gene expression disease course disease severity enzyme inhibition ex vivo study female gene identification human Humans immunophenotyping in vivo study inflammation intensive care unit Intensive Care Units lung alveolus epithelium cell lymphoid cell major clinical study male membrane protein Membrane Proteins metalloproteinase multiomics pathogenesis peripheral blood mononuclear cell protein ADAM9 protein degradation proteomics Respiration, Artificial RNA sequencing SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 unclassified drug upregulation virus cell interaction virus replication whole genome sequencing
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Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort

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