Transcriptomics Reveals How Minocycline-Colistin Synergy Overcomes Antibiotic Resistance in Multidrug-Resistant Klebsiella pneumoniae

Transcriptomics Reveals How Minocycline-Colistin Synergy Overcomes Antibiotic Resistance in Multidrug-Resistant Klebsiella pneumoniae

Multidrug-resistant Gram-negative bacteria are a rapidly growing public health threat, and the development of novel antimicrobials has failed to keep pace with their emergence. Synergistic combinations of individually ineffective drugs present a potential solution, yet little is understood about the...

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Bibliographic Details
Main Authors: Brennan-Krohn, T. (Author), Earl, A.M (Author), Grote, A. (Author), Kirby, J.E (Author), Rodriguez, S. (Author)
Format: Article
Language:English
Published: American Society for Microbiology 2022
Subjects:
Anti-Bacterial Agents
antibiotic resistance
antiinfective agent
antimicrobial activity
antimicrobial agents
antimicrobial combinations
antimicrobial synergy
colistin
Colistin
drug potentiation
Drug Resistance, Multiple, Bacterial
Drug Synergism
genetics
Klebsiella pneumoniae
microbial sensitivity test
Microbial Sensitivity Tests
minocycline
Minocycline
multidrug resistance
RNA-Seq
transcriptome
Transcriptome
transcriptomics
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