Hybrid Proteins with Short Conformational Epitopes of the Receptor-Binding Domain of SARS-CoV-2 Spike Protein Promote Production of Virus-Neutralizing Antibodies When Used for Immunization

Hybrid Proteins with Short Conformational Epitopes of the Receptor-Binding Domain of SARS-CoV-2 Spike Protein Promote Production of Virus-Neutralizing Antibodies When Used for Immunization

Abstract: Based on the previously developed approach, hybrid recombinant proteins containing short conformational epitopes (a.a. 144-153, 337-346, 414-425, 496-507) of the receptor-binding domain (RBD) of SARS-CoV-2 Spike protein (S protein) were synthesized in Escherichia coli cells as potential co...

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Main Authors: Bolshakova, T.N (Author), Dobrynina, O.Y (Author), Galushkina, Z.M (Author), Generalova, M.S (Author), Gromov, A.V (Author), Grunina, T.M (Author), Karyagina, A.S (Author), Kleymenov, D.A (Author), Krasilnikov, I.V (Author), Lunin, V.G (Author), Lyaschuk, A.M (Author), Poponova, M.S (Author), Romanovskaya-Romanko, E.A (Author), Ryazanova, A.V (Author), Sergeeva, M.V (Author), Strukova, N.V (Author), Subbotina, M.E (Author)
Format: Article
Language:English
Published: Pleiades journals 2022
Subjects:
aldolase
epitope
epitope vaccine
RBD
RBM
S protein
SARS-CoV-2
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