G6PD functions as a metabolic checkpoint to regulate granzyme B expression in tumor-specific cytotoxic T lymphocytes

Background Granzyme B is a key effector of cytotoxic T lymphocytes (CTLs), and its expression level positively correlates with the response of patients with mesothelioma to immune checkpoint inhibitor immunotherapy. Whether metabolic pathways regulate Gzmb expression in CTLs is incompletely understo...

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Bibliographic Details
Main Authors:	Colby, A.H (Author), Colson, Y.L (Author), Ding, H.-F (Author), Grinstaff, M.W (Author), Klement, J.D (Author), Liu, K. (Author), Lu, C. (Author), Oberlies, N.H (Author), Pearce, C.J (Author), Shi, H. (Author), Yang, D. (Author)
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2022
Subjects:	acetyl coenzyme A adoptive transfer aerobic glycolysis amino acid sequence animal animal cell animal experiment animal model Animals Article bioinformatics cancer immunotherapy cancer patient cancer survival CD4+ T lymphocyte CD8+ T lymphocyte cell infiltration cell proliferation cell viability controlled study cytotoxic T lymphocyte cytotoxicity disease model Disease Models, Animal enzyme activity female Female flow cytometry G6PD protein, human gene gene expression genetic transcription glucose 6 phosphate dehydrogenase Glucosephosphate Dehydrogenase glycolysis granzyme granzyme B Granzymes Gzmb gene GZMB protein, human histone acetylation human Humans immune checkpoint inhibitor immune evasion Immune Evasion immunology immunoprecipitation immunosuppressive treatment immunotherapy Immunotherapy interleukin 2 melanoma metabolic networks and pathways Metabolic Networks and Pathways metabolism Mice mouse MSTO-211H cell line natural killer cell NCI-H226 cell line nonhuman nuclear reprogramming overall survival pentose phosphate phenotype Pi3K/Akt signaling procedures programmed cell death 1 receptor programmed death 1 ligand 1 programmed death 1 receptor protein expression regulatory T lymphocyte T lymphocyte T lymphocytes T-Lymphocytes T-Lymphocytes, Cytotoxic tumor associated leukocyte tumor escape Tumor Escape tumor growth tumor microenvironment tumor volume
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G6PD functions as a metabolic checkpoint to regulate granzyme B expression in tumor-specific cytotoxic T lymphocytes

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