$Single-center experience using anakinra for steroid-refractory immune effector cell-Associated neurotoxicity syndrome (ICANS)$

Single-center experience using anakinra for steroid-refractory immune effector cell-Associated neurotoxicity syndrome (ICANS)

In addition to remarkable antitumor activity, chimeric antigen receptor (CAR) T-cell therapy is associated with acute toxicities such as cytokine release syndrome (CRS) and immune effector cell-Associated neurotoxicity syndrome (ICANS). Current treatment guidelines for CRS and ICANS include use of t...

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Bibliographic Details
Main Authors:	Chen, Y.-B (Author), Cook, D. (Author), Defilipp, Z. (Author), Dey, B. (Author), El-Jawahri, A.R (Author), Frigault, M.J (Author), Gallagher, K. (Author), Horick, N. (Author), Leick, M.B (Author), Lindell, K. (Author), Maus, M.V (Author), McAfee, S.L (Author), O'Donnell, P. (Author), Spitzer, T. (Author), Trailor, M. (Author), Wehrli, M. (Author)
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2022
Subjects:	adult Adult aged Aged anakinra Article atovaquone autologous stem cell transplantation axicabtagene ciloleucel biological marker blood sampling Burkitt lymphoma C reactive protein CD19 antigen central nervous system chimeric antigen receptor T-cell immunotherapy chimeric antigen receptors clinical article combination corticosteroid cyclophosphamide cytokine release syndrome cytokines dasatinib dexamethasone diffuse large B cell lymphoma drug efficacy drug therapy effector cell famciclovir febrile neutropenia female Female ferritin fever fluconazole follicular lymphoma gamma interferon inducible protein 10 granulocyte macrophage colony stimulating factor hematologic malignancy human Humans inflammation interleukin 1 Interleukin 1 Receptor Antagonist Protein interleukin 1 receptor blocking agent interleukin 15 interleukin 18 interleukin 1alpha interleukin 1beta interleukin 2 interleukin 2 receptor alpha interleukin 6 interleukin 6 receptor interleukin 6 receptor alpha interleukin 7 lactate dehydrogenase lactate dehydrogenase blood level lymphoblastoma macrophage inflammatory protein 1alpha macrophage inflammatory protein 1beta male Male mantle cell lymphoma middle aged Middle Aged monocyte chemotactic protein 1 multiplex polymerase chain reaction Neurotoxicity Syndromes neutropenia neutrophil count pathogenesis platelet count prophylaxis Receptors, Chimeric Antigen retrospective study ruxolitinib siltuximab steroid thrombocytopenia tisagenlecleucel T tocilizumab toxicity and intoxication tumor necrosis factor
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Single-center experience using anakinra for steroid-refractory immune effector cell-Associated neurotoxicity syndrome (ICANS)

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