Ascites and resistance to immune checkpoint inhibition in dMMR/MSI-H metastatic colorectal and gastric cancers

Ascites and resistance to immune checkpoint inhibition in dMMR/MSI-H metastatic colorectal and gastric cancers

Background Despite unprecedented benefit from immune checkpoint inhibitors (ICIs) in patients with mismatch repair deficient (dMMR)/microsatellite instability high (MSI-H) advanced gastrointestinal cancers, a relevant proportion of patients shows primary resistance or short-term disease control. Sin...

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Bibliographic Details
Main Authors: Ambrosini, M. (Author), Andre, T. (Author), Bergamo, F. (Author), Chao, J. (Author), Chida, K. (Author), Cohen, R. (Author), Colle, R. (Author), Conca, V. (Author), Corti, F. (Author), Cremolini, C. (Author), Curigliano, G. (Author), Elez, M.E (Author), Emmett, M. (Author), Fakih, M. (Author), Fenocchio, E. (Author), Fucà, G. (Author), Garciá, M.D (Author), Jayachandran, P. (Author), Kawazoe, A. (Author), Klempner, S.J (Author), Lonardi, S. (Author), Mazzoli, G. (Author), Overman, M. (Author), Pietrantonio, F. (Author), Provenzano, L. (Author), Randon, G. (Author), Salati, M. (Author), Salvatore, L. (Author), Shah, A.T (Author), Shitara, K. (Author), Svrcek, M. (Author)
Format: Article
Language:English
Published: BMJ Publishing Group 2022
Subjects:
adult
adverse event
aged
Aged
Article
ascites
Ascites
bone metastasis
cancer surgery
clinical practice
clinical trial
cohort analysis
Colorectal Neoplasms
colorectal tumor
complication
computer assisted tomography
controlled study
cytotoxic T lymphocyte antigen 4
ECOG Performance Status
electronic medical record
female
Female
follow up
gastrointestinal neoplasms
histology
human
human tissue
Humans
immune checkpoint inhibitor
Immune Checkpoint Inhibitors
immunotherapy
liver metastasis
lung metastasis
lymph node metastasis
major clinical study
male
Male
malignant neoplasm
metastasis
metastatic colorectal cancer
metastatic stomach cancer
microsatellite instability
Microsatellite Instability
mismatch repair
mortality
multicenter study
mutational analysis
Neoplasm Metastasis
nuclear magnetic resonance imaging
outcome assessment
overall survival
pathology
peritoneum metastasis
pharmacology
programmed death 1 ligand 1
programmed death 1 receptor
progression free survival
Ras protein
Retrospective Studies
retrospective study
Stomach Neoplasms
stomach tumor
survival analysis
Survival Analysis
translational medical research
translational research
tumor biomarkers
tumor localization
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