MIRO2 Regulates Prostate Cancer Cell Growth via GCN1-Dependent Stress Signaling

MIRO2 Regulates Prostate Cancer Cell Growth via GCN1-Dependent Stress Signaling

There is a continued need to identify novel therapeutic targets prostate cancer led to the identification of MIRO2 159L, which to prevent the mortality associated with prostate cancer. In this increased GCN1 binding. Importantly, MIRO2 was necessary for context, mitochondrial Rho GTPase 2 (MIRO2) mR...

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Bibliographic Details
Main Authors: Boulton, D.P (Author), Caino, M.C (Author), Cramer, S.D (Author), Ellinwood, M.L (Author), Furnish, M. (Author), Genther, V. (Author), Grofova, D. (Author), Lucia, M.S (Author), Romero, L. (Author)
Format: Article
Language:English
Published: American Association for Cancer Research Inc. 2022
Subjects:
animal
Animals
elongation factor
GCN1 protein, mouse
GCN1 protein, S cerevisiae
genetics
human
Humans
male
Male
metabolism
Mice
mouse
Peptide Elongation Factors
prostate tumor
Prostatic Neoplasms
Protein Serine-Threonine Kinases
RNA binding protein
RNA-Binding Proteins
Saccharomyces cerevisiae
Saccharomyces cerevisiae protein
Saccharomyces cerevisiae Proteins
signal transduction
Signal Transduction
transactivator protein
Trans-Activators
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