Sex-Biased ZRSR2 Mutations in Myeloid Malignancies Impair Plasmacytoid Dendritic Cell Activation and Apoptosis

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive leukemia of plasmacytoid dendritic cells (pDC). BPDCN occurs at least three times more frequently in men than in women, but the reasons for this sex bias are unknown. Here, studying genomics of primary BPDCN and modeling disease-a...

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Main Authors:	Abdel-Wahab, O. (Author), Angelot-Delettre, F. (Author), Biichle, S. (Author), Booth, C.A.G (Author), Buonamici, S. (Author), Cabal-Hierro, L. (Author), Chung, S.S (Author), Garnache-Ottou, F. (Author), Ghandi, M. (Author), Griffin, G.K (Author), Hammerman, P.S (Author), Jardin, F. (Author), Kenyon, C.M (Author), Kim, S.S (Author), Koeffler, H.P (Author), Konopleva, M. (Author), Lane, A.A (Author), Li, J. (Author), Li, Y.Y (Author), Louissaint, A., Jr (Author), Lovitch, S.B (Author), Madan, V. (Author), Morgan, E.A (Author), Pemmaraju, N. (Author), Piccaluga, P.P (Author), Seiler, M. (Author), Taylor, J. (Author), Togami, K. (Author), Weinstock, D.M (Author), Yang, H. (Author)
Format:	Article
Language:	English
Published:	American Association for Cancer Research Inc. 2022
Subjects:	agarose animal cell animal experiment animal model annexin apoptosis Apoptosis Article beta actin bone marrow cell buffer caspase cell culture cell proliferation complementary DNA controlled study CRISPR associated endonuclease Cas9 cyclophilin B cytokine data visualization dendritic cell Dendritic Cells deoxyribonuclease I DNA extraction DNA sequence female Female fetal bovine serum flow cytometry gender identity Gender Identity gene mutation genetics genomic DNA HEK293T cell line hematopoietic cell hemolysis human Humans illumina sequencing inflammation intron leukemia lipofectamine male Male metabolism mouse mutation Mutation Mycoplasma myeloid progenitor cell myeloproliferative disorder Myeloproliferative Disorders nonhuman penicillin derivative phosphate buffered saline plasmacytoid dendritic cell polymerase chain reaction proteinase inhibitor real time polymerase chain reaction ribonucleoprotein Ribonucleoproteins RNA extraction RNA splicing RNA splicing factor room temperature sequence analysis sequence homology streptomycin toll like receptor ultrasound upregulation Western blotting X chromosome ZRSR2 protein, human
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Sex-Biased ZRSR2 Mutations in Myeloid Malignancies Impair Plasmacytoid Dendritic Cell Activation and Apoptosis

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