Low-Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy

Developing strategies to inflame tumors is critical for increasing response to immunotherapy. Here, we report that low-dose radiotherapy (LDRT) of murine tumors promotes T-cell infiltration and enables responsiveness to combinatorial immunotherapy in an IFN-dependent manner. Treatment efficacy relie...

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Main Authors:	Andreatta, M. (Author), Barras, D. (Author), Benedetti, F. (Author), Berthold, D.R (Author), Bourhis, J. (Author), Carmona, S.J (Author), Corria-Osorio, J. (Author), Coukos, G. (Author), Crespo, I. (Author), Dafni, U. (Author), de Olza, M.O (Author), Dimopoulou, G. (Author), Dromain, C. (Author), Duran, R. (Author), Foukas, P. (Author), Genolet, R. (Author), Ghisoni, E. (Author), Harari, A. (Author), Herrera, F.G (Author), Imbimbo, M. (Author), Irving, M. (Author), Kandalaft, L.E (Author), Laniti, D.D (Author), Messemaker, M. (Author), Orcurto, A. (Author), Pittet, M.J (Author), Prior, J. (Author), Rodrigo, B.N (Author), Ronet, C. (Author), Rusakiewicz, S. (Author), Sarivalasis, A. (Author), Schaefer, N. (Author), Sempoux, C. (Author), Smith, T. (Author), Spill, A. (Author), Tsourti, Z. (Author), Warren, S.E (Author), Zaman, K. (Author), Zimmermann, S. (Author)
Format:	Article
Language:	English
Published:	American Association for Cancer Research Inc. 2022
Subjects:	adaptive immunity animal cell animal experiment animal model antibody Article bioluminescence cancer immunotherapy cancer radiotherapy CD4+ T lymphocyte CD8+ T lymphocyte cell infiltration cell suspension controlled study cyclophosphamide dendritic cell desertification female fetal bovine serum flow cytometry gene expression hygromycin immune checkpoint inhibitor immune response immunity immunoglobulin G antibody immunotherapy innate immunity irradiation low-dose radiotherapy luciferase mouse multiple cycle treatment nonhuman penicillin derivative phosphatidylserine protamine protein expression radiosensitivity streptomycin T lymphocyte T lymphocyte activation tumor cell line tumor microenvironment tumor vascularization
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Low-Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy

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