Implementing a Functional Precision Medicine Tumor Board for Acute Myeloid Leukemia

Implementing a Functional Precision Medicine Tumor Board for Acute Myeloid Leukemia

We generated ex vivo drug-response and multiomics profiling data for a prospective series of 252 samples from 186 patients with acute myeloid leukemia (AML). A functional precision medicine tumor board (FPMTB) integrated clinical, molecular, and functional data for application in clinical treatment...

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Bibliographic Details
Main Authors: Aittokallio, T. (Author), Brück, O. (Author), Dufva, O. (Author), Eldfors, S. (Author), Gjertsen, B.T (Author), Heckman, C.A (Author), Hellesøy, M. (Author), Kallioniemi, O. (Author), Kankainen, M. (Author), Kivinen, K. (Author), Kontro, M. (Author), Kumar, A. (Author), Kuusanmäki, H. (Author), Lehto, M. (Author), Malani, D. (Author), Mustjoki, S. (Author), Parsons, A. (Author), Porkka, K. (Author), Potdar, S. (Author), Räty, R. (Author), Saarela, J. (Author), Turunen, L. (Author), Västrik, I. (Author), Wennerberg, K. (Author), Wolf, M. (Author), Yadav, B. (Author)
Format: Article
Language:English
Published: American Association for Cancer Research Inc. 2022
Subjects:
acute myeloid leukemia
adult
allogeneic hematopoietic stem cell transplantation
apoptosis
Article
B cell lymphoma 2 protein
biological marker
bone marrow stroma cell
cancer recurrence
cancer resistance
CD135 antigen
clinical decision making
cohort analysis
controlled study
cyclin dependent kinase
cyclin dependent kinase inhibitor
dasatinib
decision making
decision support system
Decision Support Techniques
differential gene expression
drug response
drug sensitivity
Fc receptor
female
Female
Finland
flow cytometry
flow rate
gene expression
gene expression profiling
gene mutation
gene overexpression
gene sequence
heat shock protein 90
human
Humans
interleukin 15
isocitrate dehydrogenase 1
isocitrate dehydrogenase 2
Janus kinase
Janus kinase inhibitor
K ras protein
Leukemia, Myeloid, Acute
major clinical study
male
Male
measurement precision
middle aged
Middle Aged
midostaurin
molecular fingerprinting
mortality
mTOR complex 1
navitoclax
Neuroblastoma RAS viral oncogene homolog
nucleophosmin
patient care
Patient Care Team
peripheral blood mononuclear cell
personalized medicine
phosphatidylinositol 3 kinase
Precision Medicine
protein expression
protein kinase R
protein mcl 1
protein phosphorylation
remission
Remission Induction
risk factor
RNA extraction
RNA sequence
ruxolitinib
sunitinib
survival analysis
Survival Analysis
temsirolimus
toxicity testing
trametinib
transcriptomics
tumor spheroid
unclassified drug
upregulation
vasculotropin
venetoclax
whole exome sequencing
whole genome sequencing
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