Overproduction of IFNg by Cbl-b-Deficient CD8+ T Cells Provides Resistance against Regulatory T Cells and Induces Potent Antitumor Immunity

Overproduction of IFNg by Cbl-b-Deficient CD8+ T Cells Provides Resistance against Regulatory T Cells and Induces Potent Antitumor Immunity

Regulatory T cells (Treg) are an integral component of the adaptive immune system that negatively affect antitumor immunity. Here, we investigated the role of the E3 ubiquitin ligase casitas B-lineage lymphoma-b (Cbl-b) in establishing CD8+ Tcell resistance to Treg-mediated suppression to enhance an...

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Bibliographic Details
Main Authors: Chung, D.C (Author), Elford, A.R (Author), Garcia-Batres, C.R (Author), Gold, M.J (Author), Grimshaw, N. (Author), Han, S. (Author), Liu, Z.Q (Author), Ohashi, P.S (Author), Paul, M.S (Author), Sayad, A. (Author)
Format: Article
Language:English
Published: American Association for Cancer Research Inc. 2022
Subjects:
animal
Animals
Cbl protein
CD8+ T lymphocyte
CD8-Positive T-Lymphocytes
gamma interferon
genetics
Interferon-gamma
lymphoma
Lymphoma
metabolism
Mice
mouse
Proto-Oncogene Proteins c-cbl
regulatory T lymphocyte
T-Lymphocytes, Regulatory
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