Overproduction of IFNg by Cbl-b-Deficient CD8+ T Cells Provides Resistance against Regulatory T Cells and Induces Potent Antitumor Immunity
Regulatory T cells (Treg) are an integral component of the adaptive immune system that negatively affect antitumor immunity. Here, we investigated the role of the E3 ubiquitin ligase casitas B-lineage lymphoma-b (Cbl-b) in establishing CD8+ Tcell resistance to Treg-mediated suppression to enhance an...
Main Authors: | Chung, D.C (Author), Elford, A.R (Author), Garcia-Batres, C.R (Author), Gold, M.J (Author), Grimshaw, N. (Author), Han, S. (Author), Liu, Z.Q (Author), Ohashi, P.S (Author), Paul, M.S (Author), Sayad, A. (Author) |
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Format: | Article |
Language: | English |
Published: |
American Association for Cancer Research Inc.
2022
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Subjects: | |
Online Access: | View Fulltext in Publisher |
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