Matrix Gla Protein Levels Are Associated With Arterial Stiffness and Incident Heart Failure With Preserved Ejection Fraction

Matrix Gla Protein Levels Are Associated With Arterial Stiffness and Incident Heart Failure With Preserved Ejection Fraction

OBJECTIVE: Arterial stiffness is a risk factor for cardiovascular disease, including heart failure with preserved ejection fraction (HFpEF). MGP (matrix Gla protein) is implicated in vascular calcification in animal models, and circulating levels of the uncarboxylated, inactive form of MGP (ucMGP) a...

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Bibliographic Details
Main Authors: Aragam, J.R (Author), Benjamin, E.J (Author), Bhambhani, V. (Author), Bloch, D.B (Author), Boerboom, S.L (Author), Chen, Y.-C (Author), Cheng, S. (Author), Hamburg, N.M (Author), Ho, J.E (Author), Hoffmann, U. (Author), Hwang, S.-J (Author), Ichinose, F. (Author), Larson, M.G (Author), Levy, D. (Author), Lewis, G.D (Author), Li, R. (Author), Lindsay, M.E (Author), Lino Cardenas, C.L (Author), Malhotra, R. (Author), Mitchell, G.F (Author), Nguyen, C. (Author), Nicholson, C.J (Author), O'Donnell, C.J (Author), Paniagua, S. (Author), Roh, J.D (Author), Sigurslid, H.H (Author), Slocum, C. (Author), Vasan, R.S (Author), Wang, D. (Author), Yao, C. (Author), Zapol, W.M (Author)
Format: Article
Language:English
Published: Lippincott Williams and Wilkins 2022
Subjects:
animal
Animals
arterial stiffness
Arterial stiffness
Biomarker
blood
blood pressure
Blood Pressure
C57BL mouse
calcium binding protein
Calcium-Binding Proteins
Extracellular Matrix Proteins
female
Female
gene deletion
Gene Deletion
genetics
heart failure
Heart failure
Heart Failure
heart stroke volume
human
Humans
Hypertension
Longitudinal Studies
longitudinal study
male
Male
matrix Gla protein
Mice
Mice, Inbred C57BL
middle aged
Middle Aged
pathophysiology
Prospective Studies
prospective study
Pulse wave velocity
scleroprotein
Stroke Volume
Vascular Stiffness
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