Novel Small-Molecule Troponin Activator Increases Cardiac Contractile Function Without Negative Impact on Energetics

Novel Small-Molecule Troponin Activator Increases Cardiac Contractile Function Without Negative Impact on Energetics

Background: Current heart failure therapies unload the failing heart without targeting the underlying problem of reduced cardiac contractility. Traditional inotropes (ie, calcitropes) stimulate contractility via energetically costly augmentation of calcium cycling and worsen patient survival. A new...

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Bibliographic Details
Main Authors: Baka, T. (Author), Balschi, J. (Author), Hale, C. (Author), Hartman, J.J (Author), He, H. (Author), Karamanlidis, G. (Author), Liu, Q. (Author), Luptak, I. (Author), Malik, F.I (Author), Motani, A.S (Author), Nguyen, K.K (Author), Reagan, J.D (Author), Rock, B. (Author), Slater, R. (Author), Wang, C. (Author)
Format: Article
Language:English
Published: Lippincott Williams and Wilkins 2022
Subjects:
energy metabolism
hemodynamics
phosphocreatine
sarcomeres
troponin
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