B-1b Cells Possess Unique bHLH-Driven P62-Dependent Self-Renewal and Atheroprotection

B-1b Cells Possess Unique bHLH-Driven P62-Dependent Self-Renewal and Atheroprotection

Background: B1a and B1b lymphocytes produce IgM that inactivates oxidation-specific epitopes (IgMOSE) on LDL (low-density lipoprotein) and protects against atherosclerosis. Loss of ID3 (inhibitor of differentiation 3) in B cells selectively promotes B1b but not B1a cell numbers, leading to higher Ig...

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Bibliographic Details
Main Authors: Garmey, J.C (Author), Haider, A. (Author), Lutgens, E. (Author), Marshall, M. (Author), McNamara, C.A (Author), Pattarabanjird, T. (Author), Srikakulapu, P. (Author), Taylor, A.M (Author), Upadhye, A. (Author)
Format: Article
Language:English
Published: Lippincott Williams and Wilkins 2022
Subjects:
animal
Animals
atherosclerosis
Atherosclerosis
B lymphocyte
B lymphocyte subpopulation
B-Lymphocyte Subsets
B-Lymphocytes
cardiovascular diseases
genetics
human
Humans
immunoglobulin M
Immunoglobulin M
inflammation
knockout mouse
metabolism
Mice
Mice, Knockout
mouse
pathology
proliferation
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