Alveolar, Endothelial, and Organ Injury Marker Dynamics in Severe COVID-19

Rationale: Alveolar and endothelial injury may be differentially associated with coronavirus disease (COVID-19) severity over time. Objectives: To describe alveolar and endothelial injury dynamics and associations with COVID-19 severity, cardiorenovascular injury, and outcomes. Methods: This single-...

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Bibliographic Details
Main Authors:	Charland, N.C (Author), Filbin, M.R (Author), Goldberg, M.B (Author), Gonye, A.L.K (Author), Gushterova, I. (Author), Hacohen, N. (Author), Kays, K.R (Author), Khanna, H.K (Author), LaSalle, T.J (Author), Lavin-Parsons, K.M (Author), Leisman, D.E (Author), Lilley, B.M (Author), Lodenstein, C.L (Author), Manakongtreecheep, K. (Author), Margolin, J.D (Author), McKaig, B.N (Author), Mehta, A. (Author), Parry, B.A (Author), Rojas-Lopez, M. (Author), Russo, B.C (Author), Sade-Feldman, M. (Author), Sharma, N. (Author), Tantivit, J. (Author), Thomas, M.F (Author), Thompson, B.T (Author), Villani, A.-C (Author)
Format:	Article
Language:	English
Published:	American Thoracic Society 2022
Subjects:	adult Adult advanced glycation end product receptor aged Aged Alveolar epithelial cells Alveolar Epithelial Cells angiopoietin 2 angiotensin converting enzyme 2 antiviral therapy Article artificial ventilation assisted ventilation biological marker Biomarkers breathing C reactive protein cohort analysis controlled study coronavirus disease 2019 COVID-19 creatinine critical care outcome Critical Care Outcomes D dimer dendritic cell lysosome associated membrane protein disease association disease course disease severity emergency ward endothelium Endothelium endothelium injury female Female hepatitis A virus cellular receptor 1 human Humans injury intercellular adhesion molecule 1 invasive ventilation lung alveolus lung alveolus cell lung alveolus epithelium cell major clinical study male Male mean arterial pressure middle aged Middle Aged noninvasive ventilation observational study organ injury oxygen saturation pathophysiology patient acuity Patient Acuity Pulmonary Alveoli pulse oximetry remdesivir renin angiotensin aldosterone system Renin-angiotensin system Renin-Angiotensin System Respiration, Artificial respiratory distress syndrome Respiratory distress syndrome Respiratory Distress Syndrome respiratory failure SARS-CoV-2 Sequential Organ Failure Assessment Score single blind procedure steroid tocilizumab troponin I ventilated patient World Health Organization
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Alveolar, Endothelial, and Organ Injury Marker Dynamics in Severe COVID-19

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