Prolonged Retrobulbar Local Anesthesia of the Cornea Does Not Cause Keratopathy in Mice

Prolonged Retrobulbar Local Anesthesia of the Cornea Does Not Cause Keratopathy in Mice

Purpose: Prolonged local anesthesia (PLA) of the cornea is currently assumed to cause neurotrophic keratitis and is strongly discouraged. We investigate whether PLA of the cornea per se causes neurotrophic keratitis. Methods: PLA of the cornea was induced in 12 female albino BALB/c mice by retrobulb...

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Bibliographic Details
Main Authors: Innocent, C. (Author), Kohane, D.S (Author), Liu, A. (Author), Mehta, M. (Author), Zhao, C. (Author)
Format: Article
Language:English
Published: Association for Research in Vision and Ophthalmology Inc. 2022
Subjects:
adverse event
Anesthesia, Local
Anesthetics, Local
animal
animal experiment
animal model
animal tissue
Animals
Article
confocal microscopy
controlled study
cornea
Cornea
cornea injury
Corneal Dystrophies, Hereditary
enzyme linked immunosorbent assay
female
Female
fluorescein
fluorescein sodium
follow up
hereditary corneal dystrophy
histology
histopathology
immunohistochemistry
keratitis
Keratitis
keratopathy
Keratopathy
local anesthesia
local anesthetic agent
Mice
mouse
neurokinin A
Neurotrophic
neurotrophic keratopathy
neurotrophin
nonhuman
optical coherence tomography
plasma exchange
polymerization
retina hemorrhage
retrobulbar anesthesia
Retrobulbar anesthesia
slit lamp microscopy
tetrodotoxin
transmission electron microscopy
vasculotropin
visual analog scale
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