Peanut oral immunotherapy differentially suppresses clonally distinct subsets of T helper cells

Food allergy affects an estimated 8% of children in the United States. Oral immunotherapy (OIT) is a recently approved treatment, with outcomes ranging from sustained tolerance to food allergens to no apparent benefit. The immunological underpinnings that influence clinical outcomes of OIT remain la...

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Bibliographic Details
Main Authors:	Christopher Love, J. (Author), Gierahn, T.M (Author), Ginder, J.H (Author), Monian, B. (Author), Morgan, D.M (Author), Petrossian, P.M (Author), Ruiter, B. (Author), Shreffler, W.G (Author), Smith, N.P (Author), Tu, A.A (Author)
Format:	Article
Language:	English
Published:	American Society for Clinical Investigation 2022
Subjects:	adult alpha4 integrin Arachis Article CD137 ligand CD40 ligand cell fate chemokine receptor CXCR5 child Child clinical article clinical assessment clinical outcome clinical trial clonal variation comparative study controlled clinical trial controlled study desensitization Desensitization, Immunologic differential gene expression double blind procedure drug dose escalation eosinophilic esophagitis female Female gene expression level genetics helper cell human human cell Humans immunoglobulin E immunology interleukin 17 receptor beta interleukin 2 receptor alpha intervention study lymphocyte antigen receptor maintenance drug dose male Male oral immunotherapy peanut allergy peanut extract Peanut Hypersensitivity peanut protein phase 1 clinical trial phase 2 clinical trial programmed death 1 receptor protein ptgdr2 protein randomized controlled trial Receptors, Antigen, T-Cell, alpha-beta RNA-Seq single cell analysis single cell RNA seq Single-Cell Analysis T lymphocyte receptor alpha chain T lymphocyte receptor beta chain T lymphocyte subpopulation Tfh cell Th1 cell Th17 cell Th2 cell T-Lymphocytes, Helper-Inducer transcription factor FOXP3 transcription factor GATA 3 transcriptome tumor necrosis factor receptor superfamily member 9 unclassified drug
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Peanut oral immunotherapy differentially suppresses clonally distinct subsets of T helper cells

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