Sepsis promotes splenic production of a protective platelet pool with high CD40 ligand expression

Platelets have a wide range of functions including critical roles in hemostasis, thrombosis, and immunity. We hypothesized that during acute inflammation, such as in life-threatening sepsis, there are fundamental changes in the sites of platelet production and phenotypes of resultant platelets. Here...

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Bibliographic Details
Main Authors: Boudra, R. (Author), Calabrese, D.R (Author), Cleary, S.J (Author), Conrad, C. (Author), Greenland, J.R (Author), Grockowiak, E. (Author), Leavitt, A.D (Author), Looney, M.R (Author), Magnen, M. (Author), Méndez-Ferrer, S. (Author), Passegué, E. (Author), Qiu, L. (Author), Ranucci, S. (Author), Seo, Y. (Author), Swirski, F.K (Author), Valet, C. (Author), Wang, K.M (Author)
Format: Article
Language:English
Published: American Society for Clinical Investigation 2022
Online Access:View Fulltext in Publisher