Sepsis promotes splenic production of a protective platelet pool with high CD40 ligand expression
Platelets have a wide range of functions including critical roles in hemostasis, thrombosis, and immunity. We hypothesized that during acute inflammation, such as in life-threatening sepsis, there are fundamental changes in the sites of platelet production and phenotypes of resultant platelets. Here...
Main Authors: | Boudra, R. (Author), Calabrese, D.R (Author), Cleary, S.J (Author), Conrad, C. (Author), Greenland, J.R (Author), Grockowiak, E. (Author), Leavitt, A.D (Author), Looney, M.R (Author), Magnen, M. (Author), Méndez-Ferrer, S. (Author), Passegué, E. (Author), Qiu, L. (Author), Ranucci, S. (Author), Seo, Y. (Author), Swirski, F.K (Author), Valet, C. (Author), Wang, K.M (Author) |
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Format: | Article |
Language: | English |
Published: |
American Society for Clinical Investigation
2022
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Online Access: | View Fulltext in Publisher |
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