Deficiency of lncRNA SNHG12 impairs ischemic limb neovascularization by altering an endothelial cell cycle pathway

Deficiency of lncRNA SNHG12 impairs ischemic limb neovascularization by altering an endothelial cell cycle pathway

SNHG12, a long noncoding RNA (lncRNA) dysregulated in atherosclerosis, is known to be a key regulator of vascular senescence in endothelial cells (ECs). However, its role in angiogenesis and peripheral artery disease has not been elucidated. Hind-limb ischemia studies using femoral artery ligation (...

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Bibliographic Details
Main Authors: Cheng, H.S (Author), Feinberg, M.W (Author), Gross, D.A (Author), Haemmig, S. (Author), McCoy, M.G (Author), Pérez-Cremades, D. (Author), Ryan, T.E (Author), Salyers, Z. (Author), Wara, A.K.M.K (Author), Zhuang, R. (Author)
Format: Article
Language:English
Published: American Society for Clinical Investigation 2022
Subjects:
adult
angiogenesis
angiopoietin
animal
animal cell
animal experiment
animal model
animal tissue
Animals
artery ligation
Article
blood flow
cell cycle
cell migration
cell proliferation
Cell Proliferation
cohort analysis
controlled study
Endothelial Cells
endothelium cell
gain of function mutation
gastrocnemius muscle
gene
gene control
gene expression
gene function
gene identification
gene knockdown
Gene Knockdown Techniques
gene overexpression
genetics
human
human cell
human tissue
IGF2BP3 gene
in vitro study
in vivo study
insulin resistance
ischemia
Ischemia
limb ischemia
long untranslated RNA
loss of function mutation
male
Male
metabolism
Mice
mouse
muscle ischemia
Neovascularization, Physiologic
nonhuman
Notch receptor
Notch signaling
pathogenesis
Peripheral Arterial Disease
peripheral occlusive artery disease
phenotype
physiology
proteomics
RNA sequencing
RNA, Long Noncoding
SNHG12 gene
Wnt protein
Wnt signaling
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