Liquid biopsy reveals collateral tissue damage in cancer

Liquid biopsy reveals collateral tissue damage in cancer

Cancer inflicts damage to surrounding normal tissues, which can culminate in fatal organ failure. Here, we demonstrate that cell death in organs affected by cancer can be detected by tissue-specific methylation patterns of circulating cell-free DNA (cfDNA). We detected elevated levels of hepatocyte-...

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Bibliographic Details
Main Authors: Avniel-Polak, S. (Author), Brais, L. (Author), Cohen, D. (Author), Cohen, J.E (Author), Dor, Y. (Author), Glaser, B. (Author), Gotkine, M. (Author), Grinshpun, A. (Author), Grozinsky-Glasberg, S. (Author), Hubert, A. (Author), Kaplan, T. (Author), Kustanovich, A. (Author), Lehmann-Werman, R. (Author), Loftus, M.F (Author), Loyfer, N. (Author), Lubotzky, A. (Author), Magenheim, J. (Author), Makranz, C. (Author), Maoz, M. (Author), Moss, J. (Author), Mostoslavsky, R. (Author), Neiman, D. (Author), Ng, K. (Author), Ochana, B.-L (Author), Peretz, T. (Author), Piyanzin, S. (Author), Rokach, A. (Author), Salah, A. (Author), Shemer, R. (Author), Spalding, K.L (Author), Temper, M. (Author), Wolpin, B.M (Author), Zemmour, H. (Author), Zick, A. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
Biomarkers, Tumor
blood
Brain Neoplasms
brain tumor
Cell Biology
cell free nucleic acid
Cell-Free Nucleic Acids
complication
DNA methylation
DNA Methylation
early cancer diagnosis
Early Detection of Cancer
Epigenetics
genetics
Hepatocytes
human
Humans
liquid biopsy
Liquid Biopsy
liver cell
Liver Neoplasms
liver tumor
metabolism
metastasis
Molecular diagnosis
Neoplasm Metastasis
Oncology
pancreas tumor
Pancreatic Neoplasms
pathology
procedures
tumor marker
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