Collision tumors revealed by prospectively assessing subtype-defining molecular alterations in 904 individual prostate cancer foci

Collision tumors revealed by prospectively assessing subtype-defining molecular alterations in 904 individual prostate cancer foci

BACKGROUND. Prostate cancer is multifocal with distinct molecular subtypes. The utility of genomic subtyping has been challenged due to inter- and intrafocal heterogeneity. We sought to characterize the subtype-defining molecular alterations of primary prostate cancer across all tumor foci within ra...

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Main Authors: Alnajar, H. (Author), Axcrona, K. (Author), Axcrona, U. (Author), Barbieri, C.E (Author), Beg, S. (Author), Bhinder, B. (Author), Blattner-Johnson, M. (Author), Bogaard, M. (Author), Cai, P.Y (Author), Calagua, C. (Author), Chinnaiyan, A.M (Author), Croyle, J.A (Author), Elemento, O. (Author), Fontugne, J. (Author), Johannessen, B. (Author), MacDonald, T.Y (Author), Mosquera, J.M (Author), Noorzad, Z. (Author), Park, K. (Author), Rubin, M.A (Author), Sailer, V. (Author), Sanda, M.G (Author), Scherr, D.S (Author), Siddiqui, J. (Author), Skotheim, R.I (Author), Ye, H. (Author)
Format: Article
Language:English
Published: American Society for Clinical Investigation 2022
Subjects:
aprotinin
Biomarkers, Tumor
biosynthesis
dna mutational analysis
DNA Mutational Analysis
gene rearrangement
Gene Rearrangement
genetics
human
Humans
immunohistochemistry
Immunohistochemistry
male
Male
metabolism
mutation
Mutation
nuclear protein
Nuclear Proteins
pathology
phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase
prostate tumor
Prostatic Neoplasms
PTEN Phosphohydrolase
PTEN protein, human
repressor protein
Repressor Proteins
Retrospective Studies
retrospective study
RNA
RNA, Neoplasm
SPINK1 protein, human
SPOP protein, human
Trypsin Inhibitor, Kazal Pancreatic
tumor cell culture
Tumor Cells, Cultured
tumor marker
tumor suppressor protein
Tumor Suppressor Proteins
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