Air-liquid interface culture promotes maturation and allows environmental exposure of pluripotent stem cell-derived alveolar epithelium

Air-liquid interface culture promotes maturation and allows environmental exposure of pluripotent stem cell-derived alveolar epithelium

Type 2 alveolar epithelial cells (AT2s), facultative progenitor cells of the lung alveolus, play a vital role in the biology of the distal lung. In vitro model systems that incorporate human cells, recapitulate the biology of primary AT2s, and interface with the outside environment could serve as us...

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Main Authors: Abo, K.M (Author), Alysandratos, K.-D (Author), Bullitt, E. (Author), de Aja, J.S (Author), Falconer, I. (Author), Garcia-De-Alba, C. (Author), Hinds, A. (Author), Hix, O.T (Author), Huang, J. (Author), Jaenisch, R. (Author), Kim, C.F (Author), Kotton, D.N (Author), Lindstrom-Vautrin, J. (Author), Richards, A. (Author), Villacorta-Martin, C. (Author), Werder, R.B (Author), Wilson, A.A (Author)
Format: Article
Language:English
Published: American Society for Clinical Investigation 2022
Subjects:
adult
Article
cigarette smoke
cigarette smoking
controlled study
electronic cigarette vapor
environmental exposure
fetus
gene expression
human
human cell
human tissue
in vitro study
infant
interleukin 8
kinetics
lung alveolus epithelium
male
maturation
phenotype
pluripotent stem cell
transcription initiation
upregulation
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