Serum NfL levels in the first five years predict 10-year thalamic fraction in patients with MS

Serum NfL levels in the first five years predict 10-year thalamic fraction in patients with MS

Background: Serum neurofilament light chain (sNfL) levels are associated with relapses, MRI lesions, and brain volume in multiple sclerosis (MS). Objective: To explore the value of early serum neurofilament light (sNfL) measures in prognosticating 10-year regional brain volumes in MS. Methods: Patie...

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Main Authors: Anderson, M. (Author), Bakshi, R. (Author), Barro, C. (Author), Chitnis, T. (Author), Chu, R. (Author), Glanz, B.I (Author), Granziera, C. (Author), Healy, B.C (Author), Kappos, L. (Author), Kropshofer, H. (Author), Kuhle, J. (Author), Leppert, D. (Author), Lokhande, H. (Author), Paul, A. (Author), Polgar-Turcsanyi, M. (Author), Rosso, M. (Author), Saxena, S. (Author), Tauhid, S. (Author), Weiner, H.L (Author)
Format: Article
Language:English
Published: SAGE Publications Inc. 2022
Subjects:
adult
Article
assay
beta1a interferon
beta1b interferon
biological marker
biomarker
brain size
caudate
caudate nucleus
cohort analysis
cortical thickness (brain)
deep gray matter
female
glatiramer
globus pallidus
gray matter volume
human
major clinical study
male
multiple sclerosis
neurofilament light chain
neuroimaging
nuclear magnetic resonance imaging
outcome assessment
prediction
prognostic assessment
protein
putamen
quality of life
relapse
serum neurofilament light (sNfL)
single molecule array assay
thalamic fraction
thalamus
unclassified drug
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