Nonhuman glycans can regulate anti–factor VIII antibody formation in mice

Nonhuman glycans can regulate anti–factor VIII antibody formation in mice

Recombinant factor VIII (FVIII) products represent a life-saving intervention for patients with hemophilia A. However, patients can develop antibodies against FVIII that prevent its function and directly increase morbidity and mortality. The development of anti-FVIII antibodies varies depending on t...

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Bibliographic Details
Main Authors: Arthur, C.M (Author), Doering, C.B (Author), Lollar, P. (Author), Meeks, S. (Author), Shin, S. (Author), Song, X. (Author), Stowell, S.R (Author), Wang, J. (Author), Zerra, P.E (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2022
Subjects:
animal
animal cell
animal experiment
Animals
Antibodies
antibody
Antibody Formation
antibody production
antigen
antigen binding
antigen expression
Article
BHK cell line
blood clotting factor 8
blood clotting factor 8 antibody
blood clotting inhibitor
Blood Coagulation Factor Inhibitors
CHO cell line
CHO Cells
Cricetinae
Cricetulus
F8 protein, human
Factor VIII
galactose
galactose antibody
galactose antigen
genetics
hamster
hemophilia A
Hemophilia A
immunogenicity
immunology
infusion
knockout mouse
Mice
Mice, Knockout
mouse
nonhuman
polysaccharide
Polysaccharides
protein processing
Protein Processing, Post-Translational
recombinant blood clotting factor 8
recombinant protein
Recombinant Proteins
serum
unclassified drug
wild type mouse
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