The secreted tyrosine kinase VLK is essential for normal platelet activation and thrombus formation

The secreted tyrosine kinase VLK is essential for normal platelet activation and thrombus formation

Tyrosine phosphorylation of extracellular proteins is observed in cell cultures and in vivo, but little is known about the functional roles of tyrosine phosphorylation of extracellular proteins. Vertebrate lonesome kinase (VLK) is a broadly expressed secretory pathway tyrosine kinase present in plat...

Full description

Bibliographic Details
Main Authors: Bordoli, M.R (Author), De Ceunynck, K. (Author), Dilks, J.R (Author), Flaumenhaft, R. (Author), Guo, S. (Author), Ionescu, A. (Author), Italiano, J.E (Author), Merrill-Skoloff, G. (Author), Noetzli, L. (Author), Peters, C.G (Author), Revollo, L. (Author), Rosen, V. (Author), Whitman, M. (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2022
Subjects:
adenosine diphosphate
animal
animal cell
animal experiment
Animals
Article
blood clotting
Blood Platelets
cell cloning
cell granule
collagen
controlled study
cremaster arteriole
fibrin formation
gene deletion
Gene Deletion
genetic transfection
genetics
HEK293 cell line
HEK293 Cells
HEK293T cell line
human
human cell
Humans
immunoblotting
in vitro study
in vivo study
intravital microscopy
liquid chromatography-mass spectrometry
megakaryocyte
metabolism
Mice, Transgenic
mitogen activated protein kinase 1
mouse
nonhuman
pathology
PKDCC protein, human
Platelet Activation
protein defect
protein expression
protein isolation
protein kinase B
protein phosphorylation
protein purification
protein tyrosine kinase
proteinase activated receptor 4
Protein-Tyrosine Kinases
radioimmunoprecipitation
secretory pathway
thrombin
thrombocyte
thrombocyte activation
thrombocyte aggregation
thrombocyte function
thrombosis
Thrombosis
transgenic mouse
unclassified drug
vertebrate lonesome kinase
Vlk protein, mouse
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items