MICA/B antibody induces macrophage-mediated immunity against acute myeloid leukemia

MICA/B antibody induces macrophage-mediated immunity against acute myeloid leukemia

Acute myeloid leukemia (AML) is a clonal hematopoietic stem and progenitor cell malignancy characterized by poor clinical outcomes. Major histocompatibility complex class I polypeptide-related sequence A and B (MICA/B) are stress proteins expressed by cancer cells, and antibody-mediated inhibition o...

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Bibliographic Details
Main Authors: Alves da Silva, P.H (Author), Ferrari de Andrade, L. (Author), Kotini, A.G (Author), Mascarenhas, J. (Author), Papapetrou, E.P (Author), Song, X. (Author), Wucherpfennig, K.W (Author), Xing, S. (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2022
Subjects:
acute myeloid leukemia
animal
animal cell
animal experiment
animal model
Animals
antibody
Antineoplastic Agents, Immunological
Article
Bagg albino mouse
betanidine
bone marrow
C57BL mouse
CD8+ T lymphocyte
Cell Line, Tumor
clodronic acid
controlled study
cytoplasm
drug effect
Fc receptor
female
flow cytometry
gamma delta T lymphocyte
Histocompatibility Antigens Class I
histopathology
HLA antigen class 1
human
human cell
Humans
immunity
immunological antineoplastic agent
immunology
in vivo study
Leukemia, Myeloid, Acute
liposome
macrophage
Macrophages
major histocompatibility complex class i polypeptide related sequence a antibody
major histocompatibility complex class i polypeptide related sequence b antibody
male
Male
messenger RNA
MHC class I-related chain A
MICB antigen
Mice, Inbred BALB C
Mice, Inbred C57BL
mouse
myeloperoxidase
natural killer cell
natural killer cell receptor NKG2D
natural killer T cell
nonhuman
pathology
phagocytosis
Phagocytosis
pluripotent stem cell
receptor type tyrosine protein phosphatase C
romidepsin
tumor cell line
unclassified drug
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