The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML

The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML

Translocations involving the NUP98 gene produce NUP98-fusion proteins and are associated with a poor prognosis in acute myeloid leukemia (AML). MLL1 is a molecular dependency in NUP98-fusion leukemia, and therefore we investigated the efficacy of therapeutic blockade of the menin-MLL1 interaction in...

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Bibliographic Details
Main Authors: Armstrong, S.A (Author), Barwe, S.P (Author), Gopalakrishnapillai, A. (Author), Hatton, C. (Author), Heikamp, E.B (Author), Henrich, J.A (Author), Kazansky, Y. (Author), Kentsis, A. (Author), Kolb, E.A (Author), McGeehan, G.M (Author), Perner, F. (Author), Pikman, Y. (Author), Takao, S. (Author), Uckelmann, H.J (Author), Wen, Y. (Author), Wong, E.M (Author), Xu, H. (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2022
Subjects:
acute myeloid leukemia
animal
animal cell
animal experiment
animal model
animal tissue
Animals
antineoplastic agent
Article
C57BL mouse
cancer survival
CD11b antigen
Cell Line, Tumor
chromatin
controlled study
down regulation
fusion protein
gene cluster
gene expression
gene expression profiling
gene expression regulation
Gene Expression Regulation, Leukemic
gene rearrangement
Gene Rearrangement
genetics
histone lysine methyltransferase
Histone-Lysine N-Methyltransferase
IC50
in vitro study
in vivo study
Kmt2a protein, mouse
leukemia cell line
Leukemia, Myeloid, Acute
Men1 protein, mouse
metabolism
methionine
Mice
Mice, Inbred C57BL
mixed lineage leukemia protein
mouse
murine leukemia
Myeloid-Lymphoid Leukemia Protein
nonhuman
nuclear pore complex protein 98
Nuclear Pore Complex Proteins
nucleoporin
nucleoporin 98
nup98 gene
oncogene
Oncogene Proteins, Fusion
oncoprotein
phenotype
protein analysis
Protein Interaction Maps
protein protein interaction
Proto-Oncogene Proteins
retinoblastoma binding protein 2
transcription factor HoxA9
tumor cell line
tumor xenograft
unclassified drug
upregulation
vtp 50469
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