Association of clonal hematopoiesis with chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is associated with age and smoking, but other determinants of the disease are incompletely understood. Clonal hematopoiesis of indeterminate potential (CHIP) is a common, age-related state in which somatic mutations in clonal blood populations induce aber...

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Main Authors:	Barr, R.G (Author), Bick, A.G (Author), Cade, B.E (Author), Cho, M.H (Author), Correa, A. (Author), Cupples, L.A (Author), Ebert, B.L (Author), for the COPDGene Study Investigators, National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine Consortium (Author), Gharib, S.A (Author), Gibson, C.J (Author), Gogarten, S.M (Author), Honigberg, M.C (Author), Jain, D. (Author), Jaiswal, S. (Author), Lange, L.A (Author), Leventhal, M. (Author), Levy, B.D (Author), London, S.J (Author), Manichaikul, A. (Author), McConkey, M.E (Author), Miller, B.C (Author), Miller, P.G (Author), Moll, M. (Author), Natarajan, P. (Author), Neuberg, D. (Author), Niroula, A. (Author), O'Connor, G.T (Author), Oelsner, E.C (Author), Owen, C.A (Author), Qiao, D. (Author), Ramachandran, V. (Author), Redline, S. (Author), Rich, S.S (Author), Rojas-Quintero, J. (Author), Rotter, J.I (Author), Sandoval, B. (Author), Shi, W. (Author), Sholl, L. (Author), Silverman, E.K (Author), Sperling, A.S (Author), Tesfaigzi, Y. (Author), van Galen, P. (Author), Viswanathan, K. (Author), Werner, L. (Author), Yu, B. (Author)
Format:	Article
Language:	English
Published:	Elsevier B.V. 2022
Subjects:	adult adverse event animal animal cell animal experiment animal model animal tissue Animals Article asxl1 gene biobank cancer mortality cardiovascular disease causal attribution cellular secretion chronic obstructive lung disease cigarette smoking Clonal Hematopoiesis clonal hematopoiesis of indeterminate potential cohort analysis controlled study CXCL1 chemokine CXCL2 chemokine CXCL9 chemokine cytokine release disease exacerbation disease risk assessment disease severity DNA methyltransferase 3A emphysema environmental exposure eotaxin female Female forced expiratory volume gamma interferon gene gene deletion gene expression level gene frequency gene identification gene inactivation gene knockout gene loss gene mutation gene set enrichment analysis genetic association genetic risk score genetics hematopoietic cell human human cell Humans interferon lung alveolus macrophage lung cancer macrophage inflammatory protein 3alpha major clinical study male Male Mice middle aged Middle Aged molecular pathology monocyte mouse natural killer cell nonhuman odds ratio Odds Ratio phenotype pneumonia protein expression level Pulmonary Disease, Chronic Obstructive RANTES risk factor Risk Factors smoking Smoking smoking habit somatic mutation T lymphocyte tet2 gene TGF beta signaling transforming growth factor beta tumor necrosis factor type I interferon signaling type II interferon signaling upregulation whole exome sequencing Whole Exome Sequencing whole genome sequencing
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Association of clonal hematopoiesis with chronic obstructive pulmonary disease

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