Multiple myeloma cells depend on the DDI2/NRF1-mediated proteasome stress response for survival

Multiple myeloma cells depend on the DDI2/NRF1-mediated proteasome stress response for survival

Multiple myeloma (MM) cells suffer from baseline proteotoxicity as the result of an imbalance between the load of misfolded proteins awaiting proteolysis and the capacity of the ubiquitin-proteasome system to degrade them. This intrinsic vulnerability is at the base ofMMsensitivity to agents that pe...

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Bibliographic Details
Main Authors: Anderson, K.C (Author), Bianchi, G. (Author), Briere, J. (Author), Chen, T. (Author), Czarnecki, P.G (Author), Ho, M. (Author), Keith Blackwell, T. (Author), Moscvin, M. (Author)
Format: Article
Language:English
Published: American Society of Hematology 2022
Subjects:
animal cell
animal experiment
animal model
animal tissue
Article
aspartic proteinase
biogenesis
bortezomib
cancer resistance
carfilzomib
catalysis
cell nucleus
cell survival
cellular stress response
chemosensitivity
controlled study
disease exacerbation
DNA damage inducible 1 homolog 2 protein
drug cytotoxicity
enzyme activation
enzyme activity
enzyme defect
enzyme deficiency
enzyme inhibition
enzyme synthesis
female
human
human cell
in vitro study
in vivo study
interocular transfer
molecularly targeted therapy
mouse
multiple myeloma
myeloma cell
nelfinavir
nonhuman
proteasome
proteasome inhibitor
protein cleavage
protein function
protein protein interaction
protein structure
protein transport
transcription factor Nrf1
transcription initiation
unclassified drug
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