Efficacy profile of noninvasive vagus nerve stimulation on cortical spreading depression susceptibility and the tissue response in a rat model

Efficacy profile of noninvasive vagus nerve stimulation on cortical spreading depression susceptibility and the tissue response in a rat model

Background: Noninvasive vagus nerve stimulation (nVNS) has recently emerged as a promising therapy for migraine. We previously demonstrated that vagus nerve stimulation inhibits cortical spreading depression (CSD), the electrophysiological event underlying migraine aura and triggering headache; howe...

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Bibliographic Details
Main Authors: Ayata, C. (Author), Chen, S.-P (Author), Liu, T.-T (Author), Morais, A. (Author), Mulder, I. (Author), Simon, B.J (Author), Takizawa, T. (Author), Wang, S.-J (Author), Yen, J.-C (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
adult
animal experiment
animal model
animal tissue
Article
brain cortex
brain level
calcitonin gene related peptide
controlled study
Cortical spreading depression
cyclooxygenase 2
disease predisposition
dose response
electrocorticography
histopathology
immunohistochemistry
male
migraine
nerve cell plasticity
nervous system inflammation
Neuroinflammation
nonhuman
potassium chloride
protein c fos
protein expression
protein expression level
rat
rat model
Sprague Dawley rat
spreading cortical depression
tissue reaction
treatment response
Trigeminal activation
trigeminal nucleus
trigeminus ganglion
upregulation
vagus nerve stimulation
Vagus nerve stimulation
Western blotting
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