Down-regulation of the brain-specific cell-adhesion molecule contactin-3 in tuberous sclerosis complex during the early postnatal period

Background: The genetic disorder tuberous sclerosis complex (TSC) is frequently accompanied by the development of neuropsychiatric disorders, including autism spectrum disorder and intellectual disability, with varying degrees of impairment. These co-morbidities in TSC have been linked to the struct...

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Main Authors:	Anink, J.J (Author), Aronica, E. (Author), Bongaarts, A. (Author), Broekaart, D.W.M (Author), Crino, P.B (Author), Curatolo, P. (Author), Feucht, M. (Author), Hainfellner, J.A (Author), Jansen, A.C (Author), Jansen, F.E (Author), Jozwiak, S. (Author), Korotkov, A. (Author), Kotulska, K. (Author), Krsek, P. (Author), Kwiatkowski, D.J (Author), Lagae, L. (Author), Luinenburg, M.J (Author), Mijnsbergen, C. (Author), Mills, J.D (Author), Mühlebner, A. (Author), Romagnolo, A. (Author), Spliet, W.G (Author), van Hecke, W. (Author), van Rijen, P.C (Author), van Scheppingen, J. (Author), van Vliet, E.A (Author), Zamecnik, J. (Author), Zimmer, T.S (Author)
Format:	Article
Language:	English
Published:	BioMed Central Ltd 2022
Subjects:	adolescent Adolescent adult Adult Article autism Autism Spectrum Disorder autopsy bioinformatics brain Brain brain development brain tissue Cell adhesion cell adhesion molecule Cerebral cortex development child Child Child, Preschool clinical article comorbidity complication contactin contactin 3 Contactins controlled study data analysis software down regulation Down-Regulation drug resistant epilepsy Epilepsy fetus fetus control fetus development genetics histopathology human human cell human tissue Humans immunohistochemistry in situ hybridization in vitro study infancy infant Infant Infant, Newborn mental disease metabolism middle aged Middle Aged mTORopathies neuroblastoma cell neuroblastoma cell line Neurodevelopmental disorders newborn perinatal period preschool child protein expression protein isolation quantitative analysis real time polymerase chain reaction real time reverse transcription polymerase chain reaction RNA isolation RNA sequencing SH-SY5Y cell line tuberous sclerosis Tuberous Sclerosis unclassified drug Western blotting young adult Young Adult
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Down-regulation of the brain-specific cell-adhesion molecule contactin-3 in tuberous sclerosis complex during the early postnatal period

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