Neural network modeling of differential binding between wild-type and mutant CTCF reveals putative binding preferences for zinc fingers 1–2

Neural network modeling of differential binding between wild-type and mutant CTCF reveals putative binding preferences for zinc fingers 1–2

Background: Many transcription factors (TFs), such as multi zinc-finger (ZF) TFs, have multiple DNA binding domains (DBDs), and deciphering the DNA binding motifs of individual DBDs is a major challenge. One example of such a TF is CCCTC-binding factor (CTCF), a TF with eleven ZFs that plays a varie...

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Bibliographic Details
Main Authors: Banerjee, A. (Author), Foo, C.S (Author), Kaplow, I.M (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
animal
Animals
binding site
Binding Sites
Binding strength
CCCTC-Binding Factor
CTCF
Deep neural network
DNA
genetics
metabolism
Mice
Motif
mouse
Mutated transcription factor
Neural Networks, Computer
protein binding
Protein Binding
transcription factor
transcription factor CTCF
Transcription Factors
zinc
Zinc
Zinc finger
zinc finger protein
Zinc Fingers
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