High ratio of pCXCR4/CXCR4 tumor infiltrating immune cells in primary high grade ovarian cancer is indicative for response to chemotherapy

High ratio of pCXCR4/CXCR4 tumor infiltrating immune cells in primary high grade ovarian cancer is indicative for response to chemotherapy

Background: Ovarian cancer (OC) is the fifth most common malignant female cancer with a high mortality, mainly because of aggressive high-grade serous carcinomas (HGSOC), but also due to absence of specific early symptoms and effective detection strategies. The CXCL12-CXCR4 axis is considered to hav...

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Bibliographic Details
Main Authors: Berther, J.L (Author), Droeser, R.A (Author), Eichelberger, S. (Author), Güth, U. (Author), Lalos, A. (Author), Mechera, R. (Author), Muenst, S. (Author), Posabella, A. (Author), Ramser, M. (Author), Singer, G. (Author), Soysal, S. (Author), Stadlmann, S. (Author), Terracciano, L. (Author), Walther, F. (Author), Zeindler, J. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
chemokine receptor CXCR4
Chemokines
Chemosensitivity
CXCR4
CXCR4 protein, human
cystadenocarcinoma
Cystadenocarcinoma, Serous
female
Female
genetics
human
Humans
Neoplasm Recurrence, Local
Ovarian cancer
Ovarian Neoplasms
ovary tumor
pathology
PCXCR4
prognosis
Prognosis
Prognostic significance
Receptors, CXCR4
signal transduction
Signal Transduction
Tumor expression
Tumor infiltrating immune cells
tumor recurrence
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