Assessment of the diagnostic and prognostic relevance of ACAT1 and CE levels in plasma, peritoneal fluid and tumor tissue of epithelial ovarian cancer patients - a pilot study

Assessment of the diagnostic and prognostic relevance of ACAT1 and CE levels in plasma, peritoneal fluid and tumor tissue of epithelial ovarian cancer patients - a pilot study

Background: Abnormal accumulation of acyl-CoA cholesterol acyltransferase-1 (ACAT1) and ACAT1-mediated cholesterol esterified with fatty acids (CE) contribute to cancer progression in various cancers. Our findings of increased CE and ACAT1 levels in epithelial ovarian cancer (EOC) cell lines prompte...

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Bibliographic Details
Main Authors: Ayyagari, V. (Author), Brard, L. (Author), Diaz-Sylvester, P. (Author), Groesch, K. (Author), Li, M. (Author), Louis, S. (Author), Pasman, Z. (Author), Wang, X. (Author), Wilson, T. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
ACAT1
ACAT1 protein, human
acetyl coenzyme A acetyltransferase
Acetyl-CoA C-Acetyltransferase
acyltransferase
Acyltransferases
ascites fluid
Ascitic Fluid
Biomarkers, Tumor
Carcinoma, Ovarian Epithelial
CE
Epithelial ovarian cancer
genetics
human
Humans
Ki 67 antigen
Ki67
Ki-67 Antigen
neoplasm
Neoplasms, Glandular and Epithelial
Ovarian Neoplasms
ovary tumor
pathology
Pilot Projects
pilot study
prognosis
Prognosis
tumor marker
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