Interaction of obesity polygenic score with lifestyle risk factors in an electronic health record biobank

Interaction of obesity polygenic score with lifestyle risk factors in an electronic health record biobank

Background: Genetic and lifestyle factors have considerable effects on obesity and related diseases, yet their effects in a clinical cohort are unknown. This study in a patient biobank examined associations of a BMI polygenic risk score (PRS), and its interactions with lifestyle risk factors, with c...

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Bibliographic Details
Main Authors: Cade, B.E (Author), Dashti, H.S (Author), Huang, T. (Author), Karlson, E.W (Author), Miranda, N. (Author), Redline, S. (Author), Saxena, R. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
biobank
Biological Specimen Banks
BMI
body mass
Body Mass Index
Cross-Sectional Studies
cross-sectional study
electronic health record
Electronic health records
Electronic Health Records
female
Female
Gene-lifestyle interaction
genetic predisposition
Genetic Predisposition to Disease
Genetic risk
genetics
genome-wide association study
Genome-Wide Association Study
healthy lifestyle
Healthy Lifestyle
human
Humans
Lifestyle
male
Male
middle aged
Middle Aged
obesity
Obesity
Obesogenic behaviors
Phenome-wide association study
risk factor
Risk Factors
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