The m6A demethylase ALKBH5 promotes tumor progression by inhibiting RIG-I expression and interferon alpha production through the IKKε/TBK1/IRF3 pathway in head and neck squamous cell carcinoma

Background: N6-methyladenosine (m6A) RNA modification plays a critical role in various physiological and pathological conditions. However, the role of m6A modification in head and neck squamous cell carcinoma (HNSCC) remains elusive. Methods: In this study, the expression of m6A demethylases was det...

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Bibliographic Details
Main Authors:	Chang, H. (Author), He, Y. (Author), Jin, S. (Author), Li, M. (Author), Ma, H. (Author), Wang, R. (Author), Zhang, J. (Author), Zhang, Z. (Author)
Format:	Article
Language:	English
Published:	BioMed Central Ltd 2022
Subjects:	AlkB Homolog 5, RNA Demethylase ALKBH5 ALKBH5 protein, human alkylated DNA repair protein alkB homolog 5 alpha interferon animal Animals C3H mouse DEAD Box Protein 58 genetics Head and Neck Neoplasms Head and neck squamous cell carcinoma head and neck tumor human Humans I kappa B kinase I-kappa B Kinase Interferon alpha interferon regulatory factor 3 Interferon Regulatory Factor-3 Interferon-alpha IRF3 protein, human Irf3 protein, mouse messenger RNA metabolism Mice Mice, Inbred C3H mouse N6-methyladenosine Protein Serine-Threonine Kinases retinoic acid inducible protein I RIG-I RNA, Messenger Squamous Cell Carcinoma of Head and Neck TBK1 protein, human Tbk1 protein, mouse tumor microenvironment Tumor Microenvironment
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The m6A demethylase ALKBH5 promotes tumor progression by inhibiting RIG-I expression and interferon alpha production through the IKKε/TBK1/IRF3 pathway in head and neck squamous cell carcinoma

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